Model of skeletal muscle cramp and its reversal

نویسندگان

چکیده

In an accompanying paper [2], we developed the Shorten [3] model of skeletal muscle by incorporating equations such as surface calcium fluxes. further research in this paper, succeeded reproducing cramp, well its prevention and reversal, investigating contraction which regulatory networks are involved, using extended comparison with original model. Incorporation data from a traditional medicine root extracts paeony licorice one pure chemicals was modeled. The sensitivity analysis shows robustness networks. Muscle model, requires influx via L-type channel it will not occur without influx. Reduced can delay or prevent cramp. Increased interstitial potassium is implicated developing maintaining Mechanism reversal cramp wash-out extracellular increased blood flow, followed efflux sodium-calcium exchange. This first successful quantitative electrophysiological mechanical reversal.

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ژورنال

عنوان ژورنال: Physiome

سال: 2021

ISSN: ['2744-6204']

DOI: https://doi.org/10.36903/physiome.12871364.v5